HCYS – 100 TEST Reagent for Roche Cobas Integra 400 / 400+
360,00€ EXW
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Description
Reagent HCYS
100 TESTS – 05385415190 . Reagent for Biochemical Analyzer Roche Cobas Integra 400 & Cobas Integra 400+
Combine with Calset or Precicontrol shown below.
Summary
In vitro test for the quantitative determination of total L‑homocysteine in human serum and plasma on Roche/Hitachi cobas c systems. The assay can assist in the diagnosis of patients suspected of having hyperhomocysteinemia or homocystinuria. Homocysteine Enzymatic Assay is based on a novel enzyme cycling assay principle that assesses the co‑substrate conversion product instead of assessing co‑substrate or Hcy conversion products of Hcy.
In this assay, oxidized Hcy is first reduced to free Hcy which then reacts with a co‑substrate, S‑adenosylmethionine (SAM), to form methionine (Met) and S‑adenosylhomocysteine (SAH), catalyzed by a Hcy S‑methyltransferase.
SAH is assessed by coupled enzyme reactions where SAH is hydrolyzed into adenosine (Ado) and Hcy by SAH hydrolase, and Hcy is cycled into the Hcy conversion reaction to form a reaction cycle that amplifies the detection signal.
The formed Ado is immediately hydrolyzed into inosine and ammonia. In the last step, the enzyme glutamate dehydrogenase (GLDH) catalyzes the reaction of ammonia with 2‑oxoglutarate and NADH to form NAD+. The concentration of Hcy in the sample is directly proportional to the amount of NADH converted to NAD+
Withdrawal
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